New research led by Prof. Dvir Aran of the Faculty, together with Dr. Junyang Lin and colleagues in Germany, offers a new way to understand response to immunotherapy. The researchers showed that early changes in the tumor microenvironment following treatment may predict its success: a shift toward a more active immune environment, particularly one enriched with B cells, was associated with a better response and longer survival.
Using RNA sequencing data analysis and artificial intelligence, the researchers developed a molecular signature consisting of 59 genes, which was evaluated in approximately 1,300 patients.
Published in Cancer Cell, the study suggests viewing the tumor not as a fixed system, but as a dynamic system that changes in response to treatment.
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