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Using coupling between residues based on evolutionary data for protein structure analysis
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Eran Eyal (CB, School of Medicine, University of Pittsburgh)
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Thursday, 7.2.2008, 13:30
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Taub 601
Multiple sequence alignments possess important information, not only about functionally and structurally important conserved regions, but also about coupling between residues. Recently we have developed a unique method to detect such coupling based on substitution matrices of residue pairs. I will describe the method and show how it performs at structural analysis tasks as contact prediction and discrimination of decoy sets. I will then show recent results that demonstrate how correlated mutations can be used to predict quaternary structures and to detect cooperatively between drug resistance mutations in HIV-1 protease. The relation between evolutionary coupling and protein dynamics, as calculated based on normal mode analysis, will be discussed.

Host: Yael Mandel-Gutfreund
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