Israel Steinfeld (israels AT cs technion ac il) 


I'm currently a PhD student in the field of Computational Biology, at the Computer Science department in the Technion, under the supervision of Dr. Zohar Yakhini


Fields of interest

Analysis and design of high-throughput measurement technologies.


System biology.

Epigenetics and its effect on gene expression regulation.


Academic Degrees 

B.Sc. - Bioinformatics, Cum Laude, Tel Aviv University, 2000-2004

M.Sc. – Life Science, Summa Cum Laude, Tel Aviv University, 2004-2007

Thesis:  The Influence of Chromatin Modifiers on Transcription.

Advisors: Prof. Ron Shamir and Prof. Martin Kupiec


Past Projects



Multi Knowledge






Lecturer in the course “Introduction to C Language”, Winter 2011, Spring 2012, Winter 2012

TA in the course “Informatics in Molecular Biology”, Winter 2011

TA in the course “Algorithms in Computational Biology”, Spring 2010, Spring 2011

TA in the course “Introduction to C Language”, Spring 2009, Winter 2009, Spring 2010, Winter 2010

TA in the course "Laboratory for Bioinformatics Tools”, Spring 2004-2005 (TAU)

TA in the course "General Genetics", Fall 2004-2005 (TAU)



Aure MR*, Steinfeld I*, Baumbusch LO*, Liestøl K, Lipson D, Naume B, Kleivi K, Kristensen VN, Børresen-Dale AL, Lingjærde OC*, and Yakhini Z.*

Integrated analysis of copy number and expression reveals new candidate driver genes in breast cancer.

PLoS One. 2013;8(1):e53014. doi: 10.1371/journal.pone.0053014. Epub 2013 Jan 30..


Steinfeld I, Navon R, Ach R, Yakhini Z.

miRNA target enrichment analysis reveals directly active miRNAs in health and disease.

Nucleic Acids Res. 2012 Dec 2.


Rabinovich EI, Kapetanaki MG, Steinfeld I, Gibson KF, Pandit KV, Yu G, Yakhini Z, Kaminski N.

Global methylation patterns in idiopathic pulmonary fibrosis.

PLoS One. 2012;7(4):e33770. Epub 2012 Apr 10.


Enerly E*, Steinfeld I*, Kleivi K, Leivonen SK, Aure MR, Russnes HG, Rønneberg JA, Johnsen H, Navon R, Rødland E, Mäkelä R, Naume B, Perälä M, Kallioniemi O, Kristensen VN, Yakhini Z, Børresen-Dale AL.

miRNA-mRNA Integrated Analysis Reveals Roles for miRNAs in Primary Breast Tumors.

PLoS One. 2011 Feb 22;6(2):e16915.


Avraham R, Sas-Chen A, Manor O, Steinfeld I, Shalgi R, Tarcic G, Bossel N, Zeisel A, Amit I, Zwang Y, Enerly E, Russnes HG, Biagioni F, Mottolese M, Strano S, Blandino G, Børresen-Dale AL, Pilpel Y, Yakhini Z, Segal E, Yarden Y.

EGF Decreases the Abundance of MicroRNAs That Restrain Oncogenic Transcription Factors.

Sci Signal. 2010 Jun 1;3(124):ra43.


Navon R, Wang H, Steinfeld I, Tsalenko A, Ben-Dor A, Yakhini Z.

Novel rank-based statistical methods reveal microRNAs with differential expression in multiple cancer types.

PLoS One. 2009 Nov 25;4(11):e8003


Straussman R, Nejman D, Roberts D, Steinfeld I, Blum B, Benvenisty N, Simon I, Yakhini Z, Cedar H.

Developmental programming of CpG island methylation profiles in the Human genome.

Nat Struct Mol Biol. 2009 May;16(5):564-71. Epub 2009 Apr 19.


Eden E, Navon R, Steinfeld I, Lipson D, Yakhini Z.

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists.

BMC Bioinformatics. 2009 Feb 3;10(1):48.


de Smith AJ, Walters RG, Coin LJ, Steinfeld I, Yakhini Z, Sladek R, Froguel P, Blakemore AI.

Small deletion variants have stable breakpoints commonly associated with alu elements.

PLoS ONE. 2008 Aug 29;3(8):e3104.


Steinfeld I, Navon R, Ardigò D, Zavaroni I, Yakhini Z

Clinically driven semi-supervised class discovery in gene expression data.

Bioinformatics. 2008 Aug 15;24(16):i90-7.


Perry GH, Ben-Dor A, Tsalenko A, Sampas N, Rodriguez-Revenga L, Tran CW, Scheffer A, Steinfeld I, Tsang P, Yamada NA, Park HS, Kim JI, Seo JS, Yakhini Z, Laderman S, Bruhn L, Lee C

The fine-scale and complex architecture of human copy-number variation.

Am J Hum Genet. 2008 Mar;82(3):685-95. Epub 2008 Jan 24.


Steinfeld I, Shamir R and Kupiec M

A genome-wide analysis in Saccharomyces cerevisiae demonstrates the influence of chromatin modifiers on transcription.

Nat Genet. 2007 Mar;39(3):303-9.


Tanay A, Steinfeld I, Kupiec M and Shamir R

Integrative analysis of genome-wide experiments in the context of a large high-throughput data compendium.

Mol Syst Biol. 2005;1:2005.0002. Epub 2005 Mar 29.


Shamir R, Maron-Katz A, Tanay A, Linhart C, Steinfeld I, Sharan R, Shiloh Y, Elkon R

EXPANDER - an integrative program suite for microarray data analysis.

BMC Bioinformatics. 2005 Sep 21;6:232.