Time+Place: Tuesday 01/12/2015 15:00 Room 337-8 Taub Bld.
Title: Applications of Dimensionality Reduction Techniques in Genetics
Speaker: Eran Halperin - COLLOQUIUM LECTURE - Note unusual hour http://www.cs.tau.ac.il/~heran/
Affiliation: Tel-Aviv University
Host: Nir Ailon


I will present an overview of our methods for ancestry 
inference and for correction of other confounding in statistical 
analysis of genetic and epigenetic data (methylation studies). Our 
methods rely on different variants of standard dimensionality reduction
techniques such as principal component analysis, which are tailored to 
the biological application by proper modeling of the underlying biology. 
Particularly, I will introduce a new probabilistic model for genotype 
data and will show how this model results in improved accuracy of 
inference of ancestry from genotype data.

No prior knowledge in biology will be assumed in the talk.

Short Bio: 
Eran Halperin is an associate professor in Tel Aviv University's 
Blavatnik School of Computer Science and in the Department of Molecular 
Microbiology and Biotechnology. He is also affiliated as a senior 
researcher in the International Computer Science Institute in Berkeley. 
His research focuses on the intersection between genetics, algorithms, 
and statistics. Specifically, he is developing computational and 
statistical methods for the analysis of human genetic data in the 
context of disease studies. He received his doctorate in theoretical 
computer science from Tel-Aviv University in 2001, after which he held 
postdoctoral and research associate positions in the computer science 
departments of UC Berkeley and Princeton from 2001 to 2004.  He joined 
ICSI's Algorithms Group in 2005 as a senior researcher, and he joined 
Tel-Aviv University as a faculty in the end of 2008. In addition to his 
academic activities, he also served as the director of bioinformatics at 
Navigenics, a personalized genomics company, and as a member of the 
scientific advisory board in Genia Technologies, Gene by Gene, and DNA 
Nexus. He has received various awards for his research, among them the 
Intel prize for PhD, the Checkpoint prize for PhD, a Rothschild 
postdoctoral fellowship, the Krill Prize for Excellence in Scientific 
Research, and the Technion-Juludan Research Fund prize.

Desserts will be served from 14:45
Lecture starts at 15:00