Abstract:

Complex phenotypes, such as common disease, emerge from disruption of
biologic process networks and from genome-wide changes.  System-wide
molecular characterizations coupled with novel analytic methods that
utilize network structure have offered the promise of discovering these
processes.  However, the dimensionality of such analyses have left most
of this potential unrealized.  In the work described here, we
successfully apply such an integrated approach in a novel manner to
discover critical disease processes in human cancer and critical
alterations in the transition from stem-cell to differentiated cell.